焦虑和抑郁障碍共病血浆单胺类神经递质研究

A controlled study of plasma monoamine neurotransmitters in comorbid anxiety and depression

目的 :探讨血浆单胺类神经递质与焦虑和抑郁障碍共病的关系。 方法 :使用高效液相—电化学检测法测定 2 5例焦虑和抑郁障碍共病、 30例抑郁症、 2 0例焦虑症患者和 2 1例正常人的血浆去甲肾上腺素 (NE)和 5 -羟色胺 (5 - HT)浓度。 结果 :3组患者的血浆 NE浓度均显著高于正常对照组 ,但共病组与抑郁症组和焦虑症组无明显差异 ;抑郁症组的血浆 5 - HT浓度显著低于正常对照组 ,共病组和焦虑症组的血浆 5 - HT浓度与正常对照组无显著差异 ,3组患者之间血浆 5 - HT浓度也无显著差异。 结论 :血浆单胺类神经递质不能鉴别抑郁症和焦虑症 ,也不支持焦虑和抑郁障碍共病是第

Objective:To explore the relationships between comorbid anxiety and depression (CAD) and plasma monoamine neurotransmitters. Method:The plasma noradrenaline (NE) and serotonin (5-HT) levels were measured in 25 CAD,30 depression,20 anxiety patients and 21 controls by high performance liquid chromatography (HPLC) with electrochemical detection. Results:The plasma NE levels in three study groups were significantly higher than that in control group,but there were no significant differences among three study groups.The 5-HT level was significantly lower in depression group than in control group,however no significant differences were found between the other two study groups and control group,and among three study groups. Conclusion:According to the plasma monoamine neurotransmitter levels,neither can we differentiate depression from anxiety,nor support the theory that CAD is an independent disease unit.