50岁以上精神分裂症患者的认知特征

Clinical analysis of cognitive function in schizophrenic patients with age being more than 50 years old

目的 :探讨 5 0岁以上精神分裂症患者的认知损害特征及其影响因素。 方法 :对 6 0例5 0岁以上精神分裂症患者和 40例正常人进行了威斯康星卡片分类测验 (WCST)、韦氏成人智力量表(WAIS- R)、韦氏记忆量表 (WMS)、语言流利性测验 (L F)、手指敲击测验 (FTT)、简明精神病评定量表 (BPRS)及阴性症状评定量表 (SANS)等测查。 结果 :患者组的所有认知测查结果均较正常人显著减退 ,且年龄、病程 ,阴性症状及亚型对患者认知功能有显著影响。 结论 :年龄较大、病程较长、阴性症状较重及非偏执型的精神分裂症患者认知缺损严重。

Objective:To explore the characteristics and influence factors of cognitive impairment in schizophrenic patients (age≥50y). Method:Sixty schizophrenic patients and 40 normal controls were examined with Wisconsin card sorting test (WCST),Wechsler adult intelligence scale (WAIS-R),Wechsler memory scale (WMS),the language fluency test (LF),the finger tapping test (FTT),the brief psychiatric rating scale (BPRS) and the scale for the assessment of negative symptoms (SANS). Results:The cognitive functions in schizophrenia were reduced more significantly than that in controls.Age,illness duration,negative symptoms and subtype of diagnosis were associated with cognitive deficits in schizophrenia. Conclusion:The senile schizophrenic patients with long duration sever negative symptoms and non-paranoid type may have more obvious cognitive deficits.