诱发电位评价脑组织血流量的实验研究

Changes of regional cerebral blood flow and evaluated by sensorysomatic evoked potentials in the brain injury

目的:观察实验性大鼠脑损伤后不同时相点大脑皮层体感诱发电位(sensorysomaticevoked potentials,ssep)和局部血流量(regional cerebral blood flow,rCBF)的变化。方法:用流体冲击装置制作中度脑损伤模型SYD4200型神经诱发电位诊断系统监测皮层体感诱发电位,氢清除法测定大脑局部血流量。结果:中度脑损伤后rCBF明显低于伤前和正常对照组;大脑皮层体感诱发电位的潜伏期明显延长;结论:SEP的变化与脑血流量有着一定的关系,一定程度上SEP的变化可反映脑损伤后血流量的变化。

Aim: to elucidate the relationship between changes of sensorysomatic evoked potentials (Sep) and regional cerebral blood flow (rCBF), furthermore, study their role in the brain injury and secondary brain damage. Method:The rat traumatic brain injury was made by the fluid percussion device,sensorysomatic evoked potentials were detected by means of evoked potential detected system (SYD-4228 model) .regional cerebral blood flow(rCBF)was detected by means of the hydrogen clearance method. Result : latencies of Sep both P1 AND N1 were markedly delayed after TBI,and amplitudes of Sep were markedly decreased,compared with that of preinjury group;the level of rCBF was significantly lower than that of preinjury and control; there were not different between the percussion site norcontralateral site. Conclusion: the experiment evidence suggested that there were relationship between the latencies of Sep and the level of rCBF;Latencies of Sep might sign the levels of brain ischemia.