肝生素治疗慢性黄疸型乙型病毒性肝炎疗效观察——附406例临床分析

OBSERVATION OF CURATIVE EFFECT AND CLINICAL ANALYSIS OF 406 CHRONIC ICTERIC HEPATITIS B PATIENTS TREATED WITH HSS

目的 :研究肝生素和 pHGF对治疗慢性黄疸型乙型病毒性肝炎的疗效。方法 :治疗组Ⅰ 12 3例 ,治疗组Ⅱ146例 ,对照组 137例。治疗前后观察临床症状、SALT、STB和HBV的变化。结果 :经治疗 ,40 6例慢性黄疸型乙型病毒性肝炎病人临床症状全部缓解 ,疗效达 10 0 % ,治疗组Ⅰ和治疗组Ⅱ组的复常平均天数比对照组的明显缩短 (P <0 .0 1) ;治疗组Ⅰ和治疗组Ⅱ的SALT复常例数超过 95 % ,复常平均天数约 30d ,而对照组的只有 74.5 %和超过 47d(P <0 .0 1) ;治疗组Ⅰ和治疗组Ⅱ的STB复常例数约 90 % ,复常平均天数约 35d ,而对照组的只有 6 7.9%和超过 5 2d(P <0 .0 1) ;治疗组Ⅰ优于治疗组Ⅱ (P <0 .0 5 )。三组病例均对乙肝病毒清除效果欠佳 ,HBV阴转率低。结论 :慢性黄疸型乙型病毒性肝炎病人的治疗 ,应当休息充足、及时护肝治疗 ,特别是早期应用肝生素 ,保护肝细胞功能。

Objective:To observe the curative effect of HSS and pHGF on the patient with chronic icteric Hepatitis B(HB).Methods:123 patients were in treated group Ⅰ,146 patients in treated group Ⅱ,137 patients in control group.Before and after treatment,we observed the change of clinical symptoms,SALT,STB and HBV.Results:After treatment with HSS or pHGF,the symptoms of 406 patients in this treatment were catabatic significantly,the rate of curative effect was 100%,the average resuming days in treated group Ⅰand Ⅱ were shortened significantly compared with that of control group (P<0.01),and the SALT resuming rate exceeded 95%,the average days were about 30 days, compared with 74.5% and 47 days in control group (P<0.01).Similarly 90% patients in treatd group Ⅰ and Ⅱ resumed STB,the average resuming days were about 35 days,however,in control group was 67.9% and at least 52 days respectively (P<0.01).The curative effect of treated group Ⅰ excelled that of group Ⅱ.The curative effect was not good in the control group,and the negative rate of HBV was lower than that of treated group Ⅰ and Ⅱ.Conclusions:The patients with chronic icteric HB should have enough rest and the treatment of protecting liver,especially by HSS,should be given early.