内镜下酚红喷洒染色诊断胃内幽门螺杆菌感染

DIAGNOSIS OF HELICOBACTER PYLORI INFECTION OF GASTRIC MUCUS BY ENDOSCOPIC PHENOL RED TEST

目的 :通过内镜喷洒酚红溶液 ,直接观察胃内颜色改变诊断胃内幽门螺杆菌感染。方法 :14例慢性胃炎 ,11例消化性溃疡患者 ,于检查前 1天的睡前服兰索拉唑 30mg ,内镜检查时从活检孔道将 0 .1%的酚红溶液与5 %的尿素溶液喷洒于胃粘膜上 ,观察胃粘膜的颜色变化 ,分别取染色和非染色胃粘膜组织 4块 ,2块做病检查 ,2块做细菌培养。结果 :7例慢性胃炎胃粘膜染色 ,其中 5例全胃染色 ,2例胃窦染色 ;9例消化性溃疡胃粘膜染色 ,其中 2例全胃染色 ,5例胃窦染色 ,1例胃体染色 ,1例胃底染色。染色部位的病理检查、细菌培养 (除1例因消化道出血连续 3d静脉注射洛赛克 40mg为阴性外 )均阳性 ,未染色部位病理检查、细菌培养均阴性。结论

Objective:To evaluate the dignosis of Helicobacter pylori infection of human gastric mucosa in vivo by endoscopic phenol test.Methods:14 patients with chroinc gastritis and 11 patients with peptic ulcer.Each patient was gaven 30mg of lansoprazole orally at bedtime the day before the test. 0.1% phenol red with 5% urea was sprayed over the entire surface of th gastric mucosa through the biopsy forceps channel.Four biopsy specimens were taken from coloured and non-coloured areas in the stomachs.Results:Among 14 patients with chronic gastritis,5 patients were diffuse from the antrum to the cardia,2 patients localised in the autrum of the stomach,7 patients were non-coloured.Among 11 patients with peptic ulcer,2 patients were diffuse from the antrum to the cardia,5 patients localised in the antrum of the stomach,2 patients were non-coloured.Positive outcomes were gained by pathological examination and bacterial culture for the stained areas and negative outcomes for the non-stained areas.Conclusions:The endoscopic phenol red test is a workable method for diagnosis of Helicobatcter pylori infection of gastric mucus.