乙肝病毒与胃部病变及血清乙肝标记物的关系研究

RELATIONSHIP AMONG HEPATITIS B VIRUS、 GASTRIC LESION AND SERUM HBV MARKERS

目的 :通过 6 3例临床肝病病例的胃粘膜及血清乙肝标记物的分析 ,探讨胃粘膜病变与乙型肝炎之间的关系。方法 :检测 6 3例病人血清HBVM(HBsAg、HBcAg、HBV -DNA)。同时给 6 3例病人做胃镜检查 ,取胃粘膜检测HBVM。结果 :6 3例病人均有不同程度的胃十二指肠病变 ,好发部位依次为胃窦 10 0 %、十二指肠球部约 2 0 .6 %、胃体 9.15 %、胃底约 3.2 %、幽门 1.6 %。胃粘膜HBsAg、HBcAg单项阳性率约为 41% ,双项同时阳性率约 11.1%。结论 :乙型肝炎与胃部疾病关系密切 ,血清HBVM与胃粘膜HBVM不是平行关系 。

Objective:To investigate the relationship between gastric mucosal lesion and hepatitis.Methods:Hepatitis B virus markers (HBVM) (HBsAg,HBcAg,HBV-DNA) from serum and endoscopic biopsy of gastric mucosa were examined in 63 patients.Results:All the patients had gastroduodenal diseases of different degrees,the common sites of which were autrum of stomach(100%),duodenal bulb(20.6%),body of stomach(9.15%) cardia of stomach(3.2%),pylori(1.6%).The positive rate of HBsAg or HBcAg was 41%,while the positive rate of HBsAg and HBcAg was 11.1% in gastric mucosa.Conclusions:Hepatitis B is tightly associated with gastric diseases.There is no correlation between HBVM of serum and HBVM of gastric mucosa,measurement of the latter has an important clinical sinificance.