褪黑素对小鼠前列腺组织及血液中FSH、LH和睾酮的影响

Effect of melatonin on levels of follicle stimulating hormone,luteinizing hormone and testosterone in serum and histology of prostate of mice

目的 观察褪黑素 (MT)对小鼠前列腺组织及血液中黄体生成素 (LH)卵泡刺激素 (FSH)、睾酮 (T)的影响。方法 应用放射免疫法测定血浆LH、FSH、睾酮含量 ,并用形态学方法观察前列腺组织的变化。结果 MT组小鼠血液中FSH、LH、T值低于对照组 ,其前列腺组织萎缩。结论 MT可抑制小鼠前列腺组织的生长并使血液中FSH、LH。

Objective To research the effects of melatonin(MT) on histological changes and levels of follicle stimulating hormone(FSH),luteinizing hormone(LH) and testosterone(T) in serum of mice.Methods The radioimmunoassay was used in measurement of contents of FSH,LH and T in serum.The effect of MT on FSH,LH and T in the mice was observed and the effect of the MT on the prostate tissue of mice was observed by the way of morphology.Results In the MT group,the contents of FSH,LH and T were lower than that of normal group ,and the prostate tissue of the mice in MT group was atrophique.Conclusion MT can restrain the growing of the prostate tissuse of mice and it can restrain the excreting of the FSH, LH and T.