摘要
目的研究组胺对变应性鼻炎患者鼻粘膜微血管的影响。方法变应性鼻炎组28例 ,健康人组21例 ,用人体鼻粘膜微循环显微镜观察两组组胺激发试验前后鼻粘膜微血管的管径、形态和管襻数的变化。结果变应性鼻炎组组胺激发试验后鼻粘膜微血管管径较激发前增粗 ,管襻数增加 ,鼻粘膜微血管形态以灯丝状及混合状增多。健康人组组胺激发试验前后鼻粘膜微血管管径、管襻数及形态均无变化。结论变应性鼻炎患者鼻粘膜微血管对组胺的反应性较健康人高 。
Objective To study the effect of histamine on nasal mucosal microvessed in allergic rhinitis.Methods 28 patients with allergic rhinitis and 21 cases of healthy adults were studied before and after histamine challengc. The nasal mucosal microcirculation microscopy were used to observe nasal mucosal microvascular diameter,morphology and the number of loops before and after histamine challenge.Results Compared with pre_histamine challenge, the nasal mucosal microvascular diameter was wiIder, the number of loops was increased and the microvascular morphology was mainly network_like after histamine challenge in patients with allergic rhinitis.The nasal mucosal microvessel had not changed in healthy adults before and after histamine challenge. Conclusion Histamine may cause nasal microvascular dilation of allergic rhinitis which has an effect on both resistance vessels and capacitance vessels at the same time, but the effect on nasal microvessel in healthy adults is less than that in patients with allergic rhinitis.
出处
《中国微循环》
2001年第2期135-137,共3页
Journal of Chinese Microcirculation
基金
国家自然科学基金!资助项目(39200163)
广东省卫生厅医药卫生科学基金!资助课题
关键词
变应性鼻炎
鼻粘膜微血管
组胺激发试验
Allergic rhinitis
Nasal mucosal microvessel
Histamine challenge