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肝素对肾炎患者单个核细胞及其尿激酶型纤溶酶原激活剂受体的影响

Effect of heparin on mononuclear cells and its urokinase-type plasminogen activator receptor (u-PAR)in patients with glomerulonephritis
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摘要 目的 探讨肝素对肾炎患者尿液单个核细胞分布密度及其尿激酶型纤溶酶原激活剂受体表达的影响。方法 采用流式细胞术方法测定 87例肾炎患者肝素治疗前后尿液单个核细胞分布密度及其该类受体表达水平。结果 肝素治疗前肾炎患者尿液中CD3+、CD14 +和CD16+细胞分布密度显著高于正常组 (P <0 .0 1) ;肝素治疗后尿液CD3+、CD14 +和CD16+细胞分布密度显著减小 ,其中CD14 +和CD16+细胞下降比例较大 ;肝素治疗后尿液单个核细胞该类受体表达水平显著低于治疗前 (P <0 .0 1) ,降至治疗前的 1/4~ 1/3 ;尿液单个核细胞分布密度及其该类受体表达水平与 2 4h尿蛋白定量显著性相关。结论 肝素可显著抑制单个核细胞的免疫活性及其该类受体的表达 。 Objective To investigate effects of heparin on u PAR and on urinary mononuclear cell(UMC)and UMC density in patients with glomerulonephritis.Methods We tested the expression of u PAR on UMC and UMC density in 87 patients by flow cytometry.Results Before treatment of heparin,UMC CD 3 +、CD 14 +and CD 16 + cell densities in the patients were significantly higher than those in controls(P<0.01),and there was a significant difference in UMC CD 14 +andCD 16 + cell densities between proliferative and non proliferative glomerulonephritis;After treatment of heparin,the UMC densities significantly lowed;the expression of UMC u PAR significantly lowed and decreased to one fourth~one third;There was great correlation among UMC density,expressive level of UMC u PAR and 24 hour urinary protein quantity.Conclusion Heparin could significantly inhibit the activity of UMC and the expression of UMC u PAR,which diminished infiltration of UMC to kidney and renal injury induced by u PAR.
机构地区 济南军区总医院
出处 《前卫医药杂志》 2001年第3期174-175,共2页 Qianwei Journal of Medicine & Pharmacy
关键词 肝素 肾小球肾炎 尿激酶型纤溶酶原激活剂受体 Heparin Glomerulonephritis Urokinase type plasminogen activator receptor(u PAR)
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