利用Pott’s手术建立兔单侧动力性肺动脉高压模型

Establishment of Hyperkinetic Pulmonary Hypertension Model in Rabbit

【目的】利用Pott’s手术 ,在新西兰白兔建立动力性肺动脉高压模型。【方法】将兔左肺动脉与降主动脉进行侧 侧吻合 ,并将吻合口近端的左肺动脉环束 ,结扎左上肺叶动脉的上部分枝 ,使分流血液大部分进入左中、下肺叶。【结果】术后观察 1～ 3个月 ,分流兔的左肺动脉高压形成率为 86 7% ,其中 3个月组全形成左肺动脉高压并有肺小动脉的病理形态学变化。左肺动脉压力高于右肺 ,右肺小动脉的病理改变亦较左肺为轻。【结论】利用Pott’s手术可在新西兰白兔成功建立动力性肺动脉高压模型。

Objective To establish a hyperkinetic pulmonary hypertension (PH) model with Pott's operation in New Zealand rabbits. Methods Left pulmonary artery of rabbit was anastomosed side to side to the descending aorta and proximal left pulmonary artery was banded. Branches in the upper portion of the arteries in left upper lobe were ligated. Therefore, the majority of shunted blood was driven to left middle and lower lobe. Results The left PH model was established in 86.7% of the shunting rabbits 1 to 3 months post operation, and the left PH was formed in all shunting rabbits 3 months post operation with pathological changes on pulmonary arteriole. The left pulmonary arterial pressure was higher than that of right pulmonary arterial pressure and the pathological changes were less evident in the right pulmonary arteriole. Conclusion Hyperkinetic pulmonary hypertension model is successfully established with Pott's operation in New Zealand rabbits.