酸甘利胆法治疗胆石症的实验研究

An Experimental Study of Danshi Qing Tablet for Cholelithiasis

【目的】探讨酸甘利胆中药胆石清片治疗胆石症的作用机理。【方法】利用洁霉素皮下注射诱发豚鼠胆囊结石制备胆结石的动物模型 ,然后采用纯中药制剂胆石清治疗。【结果】 6周后显示 ,胆石清高、低剂量组胆汁酸含量明显高于致石对照组 ,而总胆红素及钙离子含量明显低于致石对照组 ;胆石清高剂量组成石率为 2 7.2 7% ,明显低于致石对照组 80 % (P <0 .0 5)。【结论】胆石清片对豚鼠胆结石具有一定的溶石排石作用。

Objective To study the mechanism of Danshi Qing Tablet (DQT) in treating cho lelithiasis. Methods Sixty guinea pigs were randomly allocated to five groups : Group A (normal control), Group B (model control), Group C (treated with low d osage of DQT), Group D (treated with high dosage of DQT) and Group E (treated w ith Xiaorong Gandanjieshi Tablet). Guinea pig models of cholelithiasis were esta blished by subcutaneous injection of lincomycin. Results After six weeks of treatment, the content of the bile acid (BA) was higher and the content of tota l bil irubin TBIL and Ca 2+ was lower in Group C and Group D than those in Group B. The ga llstone formation rate in Group D was 27.27%, which was lower t han that in Group B (80%), the difference being significant (P< 0.05 ). Conclusion DQT exerts a certain litholytic and lithagog ue effect for guinea pigs with cholelithiasis.