海马-杏仁核电镜改变与颞叶癫痫的关系

Relations between Changes in Ultra microstructure of Hippocampus amygdala and Temporal Lobe Epilepsy

为研究海马 杏仁核的超微结构改变与颞叶癫痫的关系 ,对 35例颞叶癫痫病人行海马 杏仁核切除术 ,并对海马 杏仁核组织进行超微结构分析。痫灶区海马神经元以神经细胞固缩、变性为著 ,并可见有髓纤维的松解和粘连。轴索萌发出的新突出物、微管及微丝在无髓纤维上不规则排列和缠绕。神经毡内突触前终末兴奋性递质小泡增多 ,嵴消失 ,粗面内质网扩张 ,多聚核糖体解聚 ,并可见大量脂褐素及脂滴 ,星形细胞轻度水肿。提示颞叶癫痫发作不仅仅是单纯的生理生化改变所引起暂时性脑功能失调 。

To analyses of the relations between the changes in ultra microstructure of hippocampus amygdala and the temporal lobe epilepsy, the normal preoperational examinations of EEG, V EEG and MRI were performed in 35 patients with temporal lobe epilepsy. The abnormal hippocampus and amygdala were resected with the intraoperative deep brain monitoring of EEG and the ultra structure examination were performed. Changes of different degrees were observed in ultra microstructure of neurons in epileptic areas. The neuro fiber was slackened and stuck together. The number of excitatory transmitters in presynaptic terminals of axospinal asymmetric synapses was increased. Rough surfaced endoplasmic reticulum(RER) was expland. Astrocytes were swollen mildly. There were more stricking changes in microstructure of all 35 cases which were observed and the changes were unifformed. The pathologic changes of the neuro in the foci play a more important role in the mechanism of the formation and the development of temporal lobe epilepsy.