从马来酸酐合成富马酸二甲酯

Synthesis of Dimethyl Fumarate from Maleic Anhydride

马来酸酐和甲醇在一水硫酸氢钠存在下发生酯化反应 ,所得产物马来酸二甲酯在光和溴存在下转化成富马酸二甲酯 .该法有操作方便、反应条件温和。

By using sodium bisulfate monohydrate as catalyst,esterification reaction takes place between maleic anhydride and methanol.Then the intermediate,dimethyl maleate is isomerized into dimethyl fumarate under light and in the presence of bromine.The method has advantages of simple operation,mild reaction conditions and higher product purity.