新生儿缺氧缺血性脑病血糖变化的临床研究

Study blood glucose changes in HIE

目的 :为探讨新生儿缺氧缺血性脑病 (HIE)血糖变化的原因及临床意义。方法 :选择日龄 1d内的HIE新生儿 10 2例 ,用试纸法测定空腹血糖。结果 :血糖异常共 52例 (51.0 % ) ,其中高血糖32例 ,低血糖 2 0例 ,前者血糖值为 14.80± 7.56mmol/L ,后者血糖值为 0 .88± 1.52mmol/L。结论 :高血糖与出生时应用糖皮质激素、肾上腺类药及HIE的严重程度等因素有关 ;低血糖与合并硬肿症、小于胎龄儿 (SGA)、大于胎龄儿 (LGA)、出生窒息等因素有关 ;出生时未用前述药物者或HIE程度较轻者血糖多数正常。

Objective: To research the causes and clinical significance of blood glucose changes in hypoxic ischemic encephalopathy(HIE).Methods:102 newborn who were born only one day were tested fasting blood glucose. Results: 52 cases blood glucose abnormal(51%), 32 cases of them were hyperglycemia(14.86±7.56mmol/L), 20 cases were hypoglycemia(0.88±0.52mmol/L), 50 cases were normal(3.82±1.52mmol/L). Conclusion:Hyperglycemia related with glucocorticoid: adrenocorticoids and the severe level of HIE. Hypoglycemia related with sclerema neonatorum adiposum、small for gestational age infant(SGA)、large for gesstational age infant(LGA) and asphxia of the newborn. The blood glucose were normal, who weren't used the drugs and with light HIE.