先天性无症状Ⅱ型单纯疱疹病毒感染患儿近期预后观察

Short-term follow-up of congenital asymptomatic HSV-Ⅱinfection in newborn infants

为观察先天性无症状Ⅰ型单纯疱疹病毒感染患儿近期生长发育情况,对12例感染婴儿及12例对照婴儿进行了为期1年的跟踪随访,检查内容包括体格测量、Bayley婴幼儿发育量表、头颅B超和脑干听觉诱发电位(BAEP)等。结果显示感染组婴儿体格发育与对照组相比,差异无显著性意义;但智能发育的差异有显著性意义(P<0.05);感染组3个月时的头颅B超异常率高于对照组,差异有显著性意义(P=0.034);12个月时的头颅B超异常率虽高于对照组,但差异无显著性意义。感染组BAEP的异常率高于对照组,差异有显著性意义(P=0.023)。提示先天性Ⅱ型单纯疱疹病毒感染对新生儿及婴儿的神经系统发育可能造成一定的不良影响,应普及孕妇HSV-Ⅱ感染的筛查,对感染者及早予抗病毒治疗。

In this study, physical growth, Baylet developmental scale, cranial sonography assessment and brain-stem audiotory evoked potential (BAEP) examination have been carried out in 12 neonates with congenital asymptomatic HSV- 11 infection and 12 unaffected neonates as normal control so as to follow up for a period of 1 year to identify the incidence of possible sequelae due to HSV- I infection. The results showed that there was no difference in physical growth but a significant difference could be noted in mental development between these 2 groups (P<0. 05). Also, the abnormality rate of neu-rosonographic assessment in affected group was much higher in affected infants at the age of 3 months (P = 0. 034, in comparison with normal control), but the difference of abnormality rate during 12 months was no more significant between 2 groups. Moreover, a significant difference could be simultaneously noted in BAEP abnormality between 2 groups (P -0. 023). Thus, from these results, it is clearly showed that HSV- 8 infection could result in a worse influence on the developing nervous system of newborn infants. It is then suggested that every pregnant woman should be routinely screened for HSV infection and should be treated with anti-viral preparations once she is identified to have HSV infection.