摘要
目的:探讨血清学指标反映慢性肝病病理分级、分期的价值。方法:以肝穿刺活检病理学检查结果为标准,比 较200例不同病理分级、分期慢性肝病病例血清学指标的差异。结果:不同病理分级、分期慢性肝病病例的天冬氨 酸转氨酶(AST)、白蛋白(Alb)、Alb/球蛋白(A/G)比值、甲脂蛋白(AFP)、γ-谷氨酰转肽酶(GGT)、α2巨球蛋白(MG)、 PGA积分、PGAA积分、PGA指数和PGAA指数存在显著差异(P<0.05);不同炎症分级病例的间接胆红素(SIB)、 甘油三酯(TG)、高密度脂蛋白(HDL)、碱性磷酸酶(ALP)和凝血酶原时间(PT)亦存在显著差异(P<0.05)。不同肝纤 维化分期病毒性肝炎病例的AST、Alb、A/G比值、转铁蛋白(TF)、AFP、GGT、α2MG、PGA积分、PGAA积分、PGA 指数和PGAA指数存在显著差异(P<0.05)。结论:血清学指标AST、Alb、A/G比值、SIB、TG、HDL、ALP、PT、 AFP、GGT、α2MG、PGA积分、PGAA积分、PGA指数和PGAA指数与肝脏炎症分级相关;AST、Alb、A/G比值、 AFP、 GGT、 α2MG、 PGA积分、 PGAA积分?
Background/Aims: To study the value of serum parameters in reflecting pathological grading and staging of chronic liver diseases. Methods: According to the histologic examination of biopsy specimens, a comparable analysis of serum parameters in pathological grades and stages of 200 cases of chronic liver diseases was made. Results: There were significant difference in serum parameters including aspartate aminotransferase (AST), albumin (Alb), Alb/globulin (A/G) ratio, serum indirect bilirubin (SIB), triglycerides (TG), high density lipoprotein (HDL), alkaline phosphatase (ALP), prothrombin time (PT), α-fetoprotein (AFP), γ-glutamyl transpeptidase (GGT), α2-macroglobublin (MG), PGA score, PGAA score, PGA index and PGAA index among pathological grades (P<0.05), in serum parameters including AST, Alb, A/G ratio, AFP, GGT, α2MG, PGA score, PGAA score, PGA index and PGAA index among pathological stages (P<0.05) and in serum parameters including AST, Alb, A/G ratio, transferrin (TF), AFP, GGT, α2MG, PGA score, PGAA score, PGA index and PGAA index among pathological stages of chronic viral hepatitis (P<0.05). Conclusions: Serum parameters including AST, Alb, A/G ratio, SIB, TG, HDL, ALP, PT, AFP, GGT, α2MG, PGA score, PGAA score, PGA index and PGAA index were correlated with the pathological grades; AST, Alb, A/G ratio, AFP, GGT, α2MG, PGA score, PGAA score, PGA index and PGAA index were correlated with the pathological stages. TF correlates with the pathological stages of chronic viral hepatitis. This indicates that some serum parameters might reflect the pathological grading and staging of chronic liver diseases.
出处
《胃肠病学》
2001年第2期78-81,共4页
Chinese Journal of Gastroenterology
基金
上海市医学发展基金重点研究项目(No.990ZDI001)资助