200例慢性肝病患者血清免疫学指标与肝纤维化指标的典型相关分析

Relationship between Indices of Serum Immunological Markers and Liver Fibrosis in Chronic Liver Diseases：Canonical Correlation Analysis of 200 Cases

目的：研究慢性肝病患者血清免疫学指标与肝纤维化指标的相关关系。方法：对２００例慢性肝病患者的８个血清免疫学指标和９个与肝纤维化有关的血清生化指标进行典型相关分析。结果：血清免疫学指标与肝纤维化指标的典型相关系数为０．８１３ ９（Ｐ＝０．０００１），在这两个因素集团相关中，血清免疫学指标中起主要作用的是免疫球蛋白ＩｇＧ、ＩｇＭ和ＩｇＡ，其次为白细胞介素－２和自然杀伤细胞；肝纤维化指标中起主要作用的是凝血酶原时间和α２巨球蛋白，其次为透明质酸和转铁蛋白。结论：机体的免疫功能和肝纤维化密切相关。

Background/Aims: To explore the correlations between the indices of serum immunological markers and liver fibrosis. Methods: Canonical correlation analysis method was used to analyze the relationships between eight indices of serum immunological markers and nine indices of serum markers of liver fibrosis. Results: The canonical coefficient between indices of serum immunological markers and liver fibrosis was 0.813 9 (P=0.000 1). Canonical structural analysis showed that immunoglobulin IgG, IgM and IgA were the first important factors among indices of serum immunological markers, while interleukin-2 and natural killer cells being the second. Among indices of liver fibrosis, prothrombin time and α2-macroglobulin were the first important factors, whereas hyaluronic acid and transferrin were the second. Conclusions: There is a close relationship between immune function and liver fibrosis.