高碘对小鼠雄性生殖影响的实验研究

The experimental study of high iodine on the male reproduction of mice

目的 探讨高碘环境对机体生殖系统的影响。方法 分别用含碘 0、5 0 0 0、10 0 0 0、2 0 0 0 0 μg/ L 的水喂养雄性小鼠 ,6周后处死 ,对小鼠的雄性生殖腺的形态和功能进行检查。结果 饮水摄碘浓度为 10 0 0 0 μg/ L及其以下时 ,碘对实验小鼠的体重等一般情况无明显影响 ,饮水摄碘浓度为 2 0 0 0 0 μg/ L 时实验小鼠体重增长减慢 ;各浓度碘对小鼠附睾重量及形态无明显影响 ,5 0 0 0 μg/ L 和 10 0 0 0 μg/ L 给碘组的睾丸相对重量均小于对照组 ,给碘组间无量效关系 ;各组间睾丸碘含量无明显差异 ;小鼠雄性性腺功能指标精子计数、精子活力精子畸形各组间均无显著差异。结论 在一定的水碘浓度及给碘时间下 。

Objective This study is aimed to know the effect of high iodine intake on the male reproduction.Methods The study mice were divided into 3 treatment groups with 5 000?10 000?20 000 μg/L high iodine drank respectively and 1 control group. All animals were sacrificed after 6 weeks administration and needed indexes were taken and analysed.Results Except for the body weight of mice in 20 000 μg/L group and testis organ rate of mice in 5 000 μg/L and 10 000 μg/L groups, there were no obvious change on morphologic and functional reproductive indexes.Conclusions High iodine intake under this special condition had no effect on the male reproduction of mice.