赛庚啶抗家兔失血性休克的研究

EFFECT OF CYPROHEPTADINE ON ANTI—SHOCK IN RABBITS

家兔24只,随机分为赛庚啶治疗组和对照组。颈动脉放血至血压5.3kPa,维持90分钟,复制晚期失血性休克模型。用药组给于赛庚啶10mg/kg后,平均动脉压,中心静脉压明显回升,肠系膜微循环显著改善,治疗后1小时,上述指标接近于休克前正常水平,2小时存活率也相应提高,与对照组此较,差异有高度显著性(p<0.01)。本研究结果表明,赛庚啶用于晚期失血性休克家兔,可使小血管扩张,毛细血管通透性减低,微循环改善,血压回升,具有良好的抗失血性休克作用。

24 New Zealand rabbits were randomly divided into a CH treated (n=12) and a control group (n=12). The model of fat e hemorrhagic Shock was made by bleeding the cervical artery to Bp5.3Kpa fora period of 90 min. After the drug's group was given CH 10mg/kg, the AMP and CVP rose obviously and the mesenteric microcirculation improved remarkably. An hour later, the various indexes with the above almost returned to normal s before the shock The survival rate relatiely increased too. Compared with the control group, the difference was highly significant (p<0.01). The present study shows that CH, which dilates the minor vasculature and improves the mircrocirculation through blocking 5-HTS_2 and histamine H_1 receptors, has a good antishock effect.