实施不同免疫模式对脊髓灰质炎病毒分离的影响

The Effect of Different Patterns of OPV Immunization on Isolation of Polio Virus from AFP Cases in Shanxi Province

山西省于 2 0 0 0年 3、4月在 92个县 (区、市 )进行了 2轮口服脊髓灰质炎疫苗 (OPV)“扫荡”式免疫活动 ,其模式不同于OPV强化免疫和常规免疫。将此期间采集的 35例急性弛缓性麻痹 (AFP)病例粪便标本病毒分离结果 ,与近年OPV常规免疫和强化免疫期间采集的AFP病例粪便标本 (2 7例和 39例 )的病毒分离结果作了比较。“扫荡”式免疫期间的AFP病例粪例标本的PV分离率为 2 8 6 % (10 /35 ) ,明显高于常规免疫的 3 7% (1/2 7)和强化免疫的 5 1% (2 /39)。将“扫荡”式免疫期间 ,在“扫荡”式免疫地区采集的AFP病例粪便标本 2 5例及其接触者粪便标本 2 0份 ,和非“扫荡”式免疫地区采集的 10例AFP粪便标本及 2 5份接触者粪便标本的病毒分结果也作了比较分析 ,“扫荡”式免疫地区AFP病例和接触者的粪便标本中PV分离率分别为 36 0 %和 10 0 % ,均明显高于非“扫荡”式免疫地区的 10 0 %和 0。

In this paper,the results of isolation of polioviruses (PV) from AFP cases were compared among routine, supplementary and mopping-up immunization of OPV A total of 101 fecal specimens of AFP cases were analyzed35 and 27 samples were collected from March to May, 2000 and from 1999 in mopping-up and routine immunizations respectively39 samples were collected after supplementary immunization in 1998 and 199910 out of 35 samples were PV positive, the PV isolation rate PV after mopping-up vaccination was 285% that was markedly higher than 37%(1/27) by routine and 52%(3/39) by supplementary immunization The results of PV isolation from 25 samples of AFP cases and 20 samples of contacts at the area conducted mopping-up immunization was compared with that of 10 specimens of AFP cases and 25 specimens of contacts at the area not conducted mopping-up vaccinationThe isolation rates of poliovirus were 360% and 100% among AFP cases and contacts respectively in mopping-up immunization area that was obviously higher than 100%(AFP cases)and 00%(contact) in area not conducted mopping-up immunizationThe different patterns of immunization affected poliovirus isolation