巯甲丙脯酸抗失血性休克兔的血小板聚集作用

ANTI-PLATELET AGGREGATIVE EFFECT OF CAPTOPRIL IN RABBITS HEMORRHAGIC SHOCK

应用PPP 自动平衡血小板聚集仪,动态观察了家兔失血性休克时及应用巯甲丙脯酸后血小板聚集率的变化。结果表明:家兔失血性休克90分钟时,血小板的聚集性显著升高(AGG〔1〕50.75±5.56%,AGG〔5〕41.96%;P<0.01);应用巯甲丙脯酸(1 mg/kg)后,血小板的聚集性显著降低(P<0.01),30分钟时其抑制率AGG〔1〕58.4%、AGG〔5〕68.23%,60分钟时其抑制率AGG〔1〕76.49%、AGG〔5〕97.56%。相关性分析表明:血小板的聚集性与MABP、CVP、肾血流量和肠系膜微循环呈高度相关性。认为巯甲丙脯酸抗血小板聚集性作用可能是抗休克机制之一。

The changes of the platelet aggregative rate were dynamically obser red with PPP automatic platlet aggregation tester in rabbits' hemorrhagic shockand after treating with captopril.The results showed that the platelet aggregationwas obviously high when rabbits' hemorrhagic shock happened at 90 minutes(AGG(1)50.75±5.56%,AGG(5)41.96±5.39%;P<0.01).After treating with captopril (1mg/kg),the platelet aggregation was significantly lowered(P<0.01).Inhibitingrates of the platelet were AGG(1)58.44 per cent,AGG(5)68.23 per cent aftertakeingdrug 30 minutes and were AGG(1)76.49 per cent,AGG(5) 97.56 per cent after60 miuntes.The correlative anglysis showed that the accessory—correlation wasobserved in the platelet aggregation and MABP,CVP,renal bloow,mesetnericmicrocirculation in rabbits' hemorrhagic shock.Anti-platelet aggregative effectof captopril may be one of mechanism of anti-shock.