留居高原时间对习服者血脂及胆红素的影响

Effect of Residential Durations in Plateau on Lipid and Bilirubin in Serum of Acclimatizated People

目的 探讨高原习服者血清总胆红素 (T- Bil)演变规律及脂代谢的变化。方法 将 140名习服者 ,按留居高原时间分为组 1(0 .5～ 1年 ,n=5 0 )、组 2 (2～ 4年 ,n=30 )、组 3(5～ 10年 ,n=30 )、组 4(>10年 ,n=30 )。检测其血清总胆红素 (T- Bil)、直接胆红素 (D- Bil)、白蛋白 (Ab)、甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白 (L DL- c)及高密度脂蛋白(HDL - C)。结果 组 1和组 2各指标差异无显著性。与组 1和组 2相比 ,组 3和组 4T- Bil显著下降 (P<0 .0 0 1)、总胆固醇 (TC)增高 (P<0 .0 5 ) ;血清直接胆红素 (D- Bil)、白蛋白 (Ab)、低密度脂蛋白 (L DL - c)、高密度脂蛋白 (HDL - c)及甘油三酯 (TG)在各组间差异均无显著性 (P>0 .0 5 )。结论 T- Bil减低及 TC增高 ,可能与留居高原习服者罹患冠心病风险增加有关 ,虽然其 TG、L DL- c和 HDL- c无变化 ;T- Bil改变与 D- Bil。

Objective To explore the regularities of the variations of the levels of the total bilirubin in serum and lipid metabolism of acclimatized people Methods 140 acclimatized soldiers were divided into 4 groups,such as 1st group (0 5～1 year, n =50),2nd group (2～4 years ,n =30),3rd group(5～10 years, n =30),and 4 th group (>10 years, n =30),based on their residential durations in plateau The levels of total bilirubin(T Bil),direct bilirubin(D Bil),albumin(Ab),triglycerides(TG),total chelesterol(TC),low density lipoprotein(LDL c),and high density lipoprotein(HDL c) in serum were determined among soldiers in 4 groups Results No significant differences were found in all observed indexes between the 1 st group and the 2nd group Significant decreases of the levels of T Bil ( P<0 001 ) and significant increases of the levels of TC ( P<0 05 ) in serum were observed in the 3rd group and the 4th group compared with those in the 1st group and 2 nd group No significant differences were observed in the levels of D Bil,Ab,LDL c,HDL c,and TG between all observed groups( P>0 05 ) Conclusion The decreases of the levels of T Bil and the increases of the levels of TC in serum might be associated with the increase of the risk of the prevalance of coronary artery disease (CAD) among acclimatized people in plateau with the residential durations of more than 5 years,in spite of no significant variations of the levels of TG,LDL c and HDL c in serum The association of variations of the levels of T Bil with the levels of D Bil and Ab in serum was not found