Ⅲa期非小细胞肺癌术后辅助放射治疗疗效分析

Postoperative radiotherapy for stage Ⅲa non-small cell lung carcinoma

目的 探讨Ⅲa期非小细胞肺癌 (NSCLC)术后预防性照射的临床意义。方法 回顾性分析 2 5 0例Ⅲa期NSCLC患者术后放射治疗与未放射治疗的生存率及复发情况。其中术后放射治疗115例 ,未放射治疗 135例。肺鳞癌 136例 ,放射治疗 70例 ,未放射治疗 6 6例。肺腺癌 75例 ,肺鳞腺癌及其它类型 39例。结果 术后放射治疗 5年生存率为 2 4.3% ,未予放射治疗 5年生存率为14.2 % ,两组比较有显著差别 (P <0 .0 5 )。肺鳞癌术后放射治疗 5年生存率 (2 6 .7% )明显高于未放射治疗者 (14.6 % ) (P <0 .0 5 )。结论 能手术切除的Ⅲa期非小细胞肺癌术后应给予预防性照射 。

Objective To evaluate the results of postoperative radiotherapy for stage Ⅲa non small cell lung carcinoma (NSCLC). Methods Two hundred and fifty patients with stage Ⅲa NSCLC were retrospectively reviewed. One hundred and thirty six patients had squamous cell carcinoma, 75 adenocarcinoma, and 39 others. One hundred thirty five patients received surgery alone and 115, surgery plus postoperative radiotherapy. Of 136 patients with squamous cell carcinoma, 70 patients were treated with surgery plus postoperative radiotherapy, and 66 with surgery alone. Results The 5 year survival rates were 24.3% for surgery plus radiotherapy and 14.2% for surgery alone. The difference in the survival was statistically significant (P<0.05). The survival rate for patients with squamous cell carcinoma was better in surgery plus radiotherapy as compared to surgery alone, with 5 year survivals of 26.7% and 14.6%, respectively (P<0.05). Conclusions Postoperative radiotherapy is able to improve the survival rate for patients with stage Ⅲa NSCLC.