胃十二指肠溃疡病危险因素病例对照研究

A Matched Case-control Study in 103 Gastric and Duodenal Ulcer Patients and Controls

目的 :探讨胃十二指肠溃疡发病危险因素的联合暴露情况对本病的影响。方法 :对经胃镜确诊的 10 3例胃十二指肠溃疡病患者行 1∶1配对的病例对照研究。结果 :①阳性家族史、暴饮暴食、吸烟、进餐不规律 ,是胃十二指肠溃疡病的危险因素 ,其OR值分别为 4 0、4 4、4 5、5 ;饮酒、服药史、喜食刺激性食物等与胃十二指肠溃疡发病无统计学联系。吸烟与进餐不规律、吸烟与暴饮暴食在本病的发病过程中呈较强的协同作用 ,OR值为 9 18、8 2 6。②在SCL - 90项临床症状自评量表方面 ,各因子病例组明显高于对照组 (P <0 0 5 ) 。结论 :阳性家族史、暴饮暴食、吸烟、进餐不规律 ,性格方面抑郁、焦虑症状能诱发胃十二指肠溃疡 。

Objective:To study the impacts of risk factors on gastric and duodenal ulcer.Methods:A matched case-control study was conducted in 103 gastric and duodenal ulcer patients diagnosed by gastroscope and controls.Results:1.Positive family history,engorgement,smoking,irregular eating were risk factors of gastric and duodenal ulcer.The ORs were respectively 4.0,4.4,4.5,5.Alcohol,taking medicine(Aspirin or Cortex Steroid Hormone),exciting diets had no statistic relation with gastric and duodenal ulcer.Smoking cooperated strongly with irregular eating,engorgement in resulting in gastric and duodenal ulcer.The ORs were respectively 9.18 and 8.26.2.By SCL-90 items of clinical symptoms for self-scaling,scores in cases were significantly and respectively higher than that in controls(P<0 05).Conclusion:Positive family history,engorgement,smoking,irregular eating,depression and anxiety can induce gastric and duodenal ulcer and thus increase its incidence.