两种不同方案治疗儿童幽门螺杆菌相关性胃炎的疗效评价

A evaluation of two different therapy on helicobacter pylori-related gastritis in children

目的:评价两种方案治疗幽门螺杆菌感染的疗效。方法:３２例患儿经胃镜检查确诊为幽门螺杆菌(ＨＰ)相关性胃上,随机分为Ａ、Ｂ组,分别接受ＣＢＳ＋ＡＭＯ＋ＦＵＲ和ＣＢＳ＋ＡＭＯ＋Ｍｅｔ(标准三联疗法)治疗。结果:Ａ组在ＨＰ根除率、胃窦部粘膜炎症的恢复、腹痛缓解时间方面均优于或等于Ｂ组,Ａ组不良反应发生率低于Ｂ组。结论:含呋喃唑酮的三联方案在治疗儿童幽门螺杆菌感染方面有较大价值,值得进一步研究。

Objective: To evaluate the therapeutic effect of two different programs consist of colloidal bismuth subsilrale(CBS) plus amoxicillin(AMO) furazolidone(FUR) in comparision with standard triple threapy on Helicobacter pylori (HP) -related gastritis in children. Methods:Thirty-two children(3 to 13 years old)with gaslroscopically confirmed HP-related gastritis were divided into 2 groups( A , B)al random. These children were given two different triple therapies. Group A was given CBS 8 mg/(kg.d) for two weeks, AMO 50 mg/ (kg. d) for two weeks, FUR 5 mg/(kg.d) for one week. Group B was given a standard triple therapy (CBS + AMO + Met), dosage of CBS ^ AMO was the same above, Met 15 mg/(kg. d) for two weeks. Gastroscopy was performed in these patients prioer to medication and over 4 weeks after threapy, HP infection was detected by rapid urease test and histology over 4 weeks after the therapy. All the patients completed the whole study. Results: (1) The eradication rates of HP were as follow: Group A 94. 10% (16/17), Group B 86. 6% (13/ 15) . The differences were not significant. (2) 1 and 2 week after threapy, the pain relief rates in Group A were 70. 6% (12/17) and 100% (17/17)respectively. Group B were 73. 3% (ll/15)and 86. 6% (13/15). (3)The side-effects in the two groups(nausea vomiting diarrhea and a few rashes )were mild. The ocurence rates in groups A and B were 6% and 13% respectively. Conclusion: The same efiecl was achieved in treatment of HP-related gastritis between two different triple therapies (CBS + AMO -f FUR and CBS + AMO + Met). Low dose of FUR for a week was highly effective and well tolerated in treatment of HP-related gastritis in children. The side-effects were minor therefore, the triple therapy composed of CBS + AMO + FUR seemed to be of great value with the standard thriple therapy and a worthy of study.