正清风痛宁治疗骨关节炎的疗效及副作用

Therapeutic Effects and Side Effects of Zhengqingfengtongning in the Treatment of Osteoarthritis

目的观察正清风痛宁对骨关节炎 (OA)的疗效及氯苯吡胺能否作为正清风痛宁的协同药同时服用以减轻其组胺释放所致的副作用。方法 6 0例患者分为 A B2组 ,A组服正清风痛宁 6 0 m g,1日 3次 ,服 4周 ,氯苯吡胺4m g,1日 3次 ,第 1,2周服。 B组服正清风痛宁 6 0 m g,1日 3次 ,服 4周。结果经过 4周治疗 ,2组各项观测指标均改善 ,治疗前后差异有显著性 ,均 P<0 .0 0 1。A组加服氯苯吡胺其不良反应发生率及程度皆低于 B组 ,但 2组统计分析差异无显著性。正清风痛宁治疗 OA疗效显著。氯苯吡胺虽能改善皮肤症状 ,但对头及胃痛改善不明显 ,并出现口干和嗜睡副作用。结论氯苯吡胺为 H1 受体阻滞剂 ,对 H2 受体无作用 。

Objective To observe the therapeutic effects of Zhengqingfengtongning (ZQFTN) in the treatment of osteoarthritis (OA) and the synergic action of chlortrimeton to reduce the histamine induced side effects. Methods Sixty patients with OA were divided into group A (orally taking ZQFTN 60 mg, t.i.d for 4 weeks, chlortrimeton 4 mg, t.i.d, on the first and second week) and group B (orally taking ZQFTN 60 mg, t.i.d for 4 weeks). Results After 4 week treatment, the various parameters in the two groups were all improved significantly (both P <0 001). The occurrence of side effects in the group A was lower and severity milder than in the group B ( P >0 05). ZQFTN had a prominent efficacy for OA. Chlortrimeton could improve skin symptoms, but it could not obviously improve the headache and stomach pain and the side effects such as xerostomia and lethargy occurred. Conclusion It was not necessary to routinely take chlortrimeton during the administration of ZQFTN.