精神分裂症患者一氧化氮合酶活性与发病机制相关性

The Nitric Oxide Synthase Activity in Schizophrenia and its Relation with Pathogenesis

目的通过测定首发精神分裂症患者和正常人的血清一氧化氮合酶 (NOS)活性 ,比较和分析他们之间的差异 ,探讨 NOS活性以及一氧化氮 (NO)能神经系统的功能变化与精神分裂症的关系。方法采用比色法分别测定首发未用抗精神病药的精神分裂症患者 (研究组 )、临床症状缓解的精神分裂症患者 (缓解组 )和正常对照者的血清NOS活性。结果研究组的血清 NOS活性为 6 .36 6 5± 1.2 2 6 0 (n=39) ,明显高于症状缓解组 (4 .12 0 4± 0 .990 8,n=2 7,P<0 .0 1)和正常对照组 (3.2 6 6 0± 1.0 32 0 ,n=2 7,P<0 .0 1) ;症状缓解组的 NOS活性也明显高于正常对照组(P<0 .0 1)。结论精神分裂症患者血清 NOS活性明显增高 ,L-精氨酸 - NO神经通路功能的紊乱可能是精神分裂症的发病机制之一 。

Objective To investigate the relationship between nitric oxide synthase (NOS) activity and schizophrenia. Methods The subjects were divided into three groups: the first episode schizophrenics having not taken antipsychotics and other psychotropics (study group), the relieved schizophrenics and the normal subjects (control group). The serum NOS activity was measured by using colorimetry. Results The NOS activity in the study group was 6 3665±1 2260( n =39), significantly higher than in the remission group (4 1204±0 9908, n=27, P <0 01) and control group (3 2660±1 0320, n=27, P <0 01). The NOS activity in the remission group was obviously increased as compared with that in the control group ( P <0 01). Conclusion The serum NOS activity in the patients with schizophrenia was obviously increased, indicating that the abnormal alteration in NO neuronal pathway function plays an important role in the onset of schizophrenia. NO neuronal pathway may become the new target system of antipsychotics.