消化系统恶性肿瘤血浆D-二聚体的检测及临床意义

ASSAY AND CLINIC SIGNIFICANCE OF PLASMA D-DIMER IN GASTROINTESTINAL CARCINOMAS

用ELISA双抗体夹心法分别测定52例消化系统恶性肿瘤患者和20例正常对照组血浆D-二聚体含量,结果前者显著高于后者(P<0.05);在肿瘤组中以胃癌最高,依次为食管癌、原发性肝癌和大肠癌,胃癌与大肠癌相比有显著性差异(P<0.05),余各组间无显著性差异(P>0.05)。19例肿瘤患者术后D-二聚体明显低于治疗前(P<0.01),提示动态测定D-二聚体水平变化对肿瘤患者的病情判断和疗效观察具有重要意义。

The levels of plasma D-dimer were measured by sandwich ELISA in 52 patients with gastrointestinal carsmomas and 20 healthy subjects. The results showed that the plasma D-dimer levels in the carcinoma patients were higher than those of the healthy controls ( P <0. 05). A-mong the carcinoma patients gastric carcinoma was the highest. There were significant differences in the plasma D-dimer levels between the gastric carcinoma patients and the colorectal carcinoma patients ( P <0. 05). The plasma D-dimer levels of 19 postoperative gastrointestinal carcinoma patients were significantly lower than the levels obtained before operation ( P <0. 01) . These results suggest that dynamic assay of plasma D-dimer level is important for the assessment of the clinical condition and the response to medical intervention in gastrointestinal carcinoma.