复发性葡萄膜炎患者免疫复合物测定及意义

Changes and significance of the circulating immunocomplexes in patients with recurrent uveitis

目的 探讨循环免疫复合物的含量变化在慢性前葡萄膜炎患者中的作用及意义。方法 应用生化分析仪中的紫外分光部分进行检测。结果 观察组急性期免疫复合物的含量为 2 7.35 8± 6 .92 7,观察组恢复期 16 .2 48± 6 .2 33;对照组为 13.45 9± 6 .16 4。观察组急性期与恢复期比较及急性期与对照组比较均有非常显著性差异 (P<0 .0 0 1)。结论 前葡萄膜炎急性期患者的 CIC显著升高 ,恢复期患者 CIC水平下降 ,说明此病复发与免疫复合物沉积密切相关 ,CIC的检测可作为葡萄膜炎疗效的衡量标准。

Objective To explore the changes and significance of the circulating immunocomplexes(CIC) in patients with chronic iridocyclitis.Methods We assessed circulating immunocomplexes in peripheral blood of 45 patients with recurrent uveitis and 42 healthy controls by PEG deposition with the biochemical analyzer to obtain levels of CIC different with recurrent uveitis.Results Levels of CIC were significantly higher in active patients(27.358±6.729)than those in controls(13.459±6.164, P <0.001) and inactive patients (16.248±6.233, P <0.001),but patients (inactive) had significantly higher levels than those in controls ( P <0.05).Conclusion Levels of CIC were found in the groups of active patients with recurrent uveitis (27.358±6.729), but levels of CIC in inactive patients fell. The result of this study suggest that recurrence of uveitis is related to immunocomplexes,and changes in the levels of CIC could be also a measure standard of therapeutic effects.