先天性泌尿生殖系统结构畸形危险因素的研究

A study on the risk factors of congenital urogenital malformations

目的 探讨有关因素在先天性泌尿生殖系统结构畸形发病中的作用。方法 采用成组匹配的病例对照研究方法 ,对 95例患先天性泌尿生殖系统畸形的围产儿和 16 0例对照围产儿及其父母的情况进行调查。采用非条件logistic回归模型进行多因素分析 ,计算OR值及OR的 95 %可信限。结果 先天性泌尿生殖系统结构畸形多发生于男性围产儿 (性别构成比为 74.7% ,χ2 =74.86 3,P =0 .0 0 1)。多元逐步回归分析表明 :母亲孕早、中期感冒 (OR =7.0 34 ,95 %CI =3.488～ 14.187)、低出生体重 (OR =4.0 75 ,95 %CI =1.774～ 9.36 2 )、孕次≥ 2 (OR =3.133,95 %CI =1.5 14～ 6 .483)及母亲孕前职业性接触有害化学物质 (OR =10 .496 ,95 %CI=1.0 5 3～ 10 4.6 5 1)为先天性泌尿生殖系统结构畸形的危险因素。结论 胎儿男性性别 ,母亲孕早、中期感冒 ,低出生体重 ,母亲孕次≥

Objective To explore risk factors for congenital urogenital malformations. Methods A hospital based category matching case control study was performed to investigate the characteristics of 95 cases with congenital urogenital malformations and 160 controls. Parents were interviewed for their characteristics before and during conception. Unconditional logistic regression analysis was used for single factor and multivariate analysis to estimate odds ratios and their 95% confidence intervals. Results There were 71 male infants in the overall congenital urogenital malformations( Ratio = 74.4 %,χ 2= 74.863 , P = 0.001 ) identified. Statistically significant associations were calculated for the pregnant women suffering from cold during first and/or second trimester ( OR = 7.034 ,95%CI= 3.488 - 14.187 ), for a low birthweight delivery ( OR = 4.075 ,95%CI= 1.774 - 9.362 ), for maternal times of pregnancy ≥2 ( OR =3.133 ,95%CI= 1.514 - 6.483 ) and exposure to occupational detrimental chemicals before pregnancy ( OR = 10.496 ,95%CI= 1.053 - 104.651 ). Conclusions The risk factors of congenital urogenital malformations were suffering from cold during first and/or second trimester, male infants, low birthweight delivery, times of pregnancy ≥2 and exposure to occupational detrimental chemicals before pregnancy.