摘要
分别以三 ( 2 苯并咪唑亚甲基 )胺 (NTB)和二 ( 2 苯并咪唑亚甲基 )胺 (N3)为配体 ,合成了四种Cu ,Zn超氧化物歧化酶 (SOD)的模拟化合物 [Cu(NTB) (ClO4) 2 ·CH3OH·3H2 O ,Cu(NO3) 2 ·NTB·2CH3OH·3H2 O ,Cu(NO3) 2 ·N3·4CH3OH ,Cu(ClO4) 2 ·N3·6CH3OH·6H2 O],并对它们进行了红外、紫外谱图表征 ,利用邻苯三酚自氧化法检测了活性 .活性数据值表明 ,配合物具有抑制O2 .-的活性 .其中Cu(ClO4) 2 ·N3·6CH3OH·6H2 O的活性高于其它配合物 ,IC50 =4.
Using tris(2 benzimidazolylmethyl)amine (NTB) and bis(2 benzimidazolylmethyl)amine (N 3) as ligands, four superoxide dismutase mimic complexes were synthesized. They were not only characterized with IR and UV spectra, but also assayed by means of improved pyrogallol autoxidation. Active date of IC 50 and pI 50 shows that the complexes are able to inhibit superoxide radically. The activity of (2 benzimidazolylmethyl)amine dichlorate Cu(Ⅱ) hexahydrate hexamethanol is higher than others, IC 50 =4.34 .
出处
《天津师范大学学报(自然科学版)》
CAS
2001年第2期1-4,共4页
Journal of Tianjin Normal University:Natural Science Edition
基金
天津市教育委员会重点学科资助项目 (LD - 972 0 2 )
关键词
二(2-苯并咪唑亚甲基)胺
合成
活性
铜锌超氧化物歧化酶
模拟化合物
tris(2 benzimidazolylmethyl)amine (NTB)
bis(2 benzimidazolylmethyl)amine (N 3)
synthesis
activities
superoxide dismutase(SOD)
mimic complexes