铜锌超氧化物歧化酶模拟化合物的合成与活性研究

Studies on the Synthesis and Activities of Cu,Zn Superoxide Dismutase Mimic Complexes

分别以三 ( 2 苯并咪唑亚甲基 )胺 (NTB)和二 ( 2 苯并咪唑亚甲基 )胺 (N3)为配体 ,合成了四种Cu ,Zn超氧化物歧化酶 (SOD)的模拟化合物 [Cu(NTB) (ClO4) 2 ·CH3OH·3H2 O ,Cu(NO3) 2 ·NTB·2CH3OH·3H2 O ,Cu(NO3) 2 ·N3·4CH3OH ,Cu(ClO4) 2 ·N3·6CH3OH·6H2 O],并对它们进行了红外、紫外谱图表征 ,利用邻苯三酚自氧化法检测了活性 .活性数据值表明 ,配合物具有抑制O2 .-的活性 .其中Cu(ClO4) 2 ·N3·6CH3OH·6H2 O的活性高于其它配合物 ,IC50 =4.

Using tris(2 benzimidazolylmethyl)amine (NTB) and bis(2 benzimidazolylmethyl)amine (N 3) as ligands, four superoxide dismutase mimic complexes were synthesized. They were not only characterized with IR and UV spectra, but also assayed by means of improved pyrogallol autoxidation. Active date of IC 50 and pI 50 shows that the complexes are able to inhibit superoxide radically. The activity of (2 benzimidazolylmethyl)amine dichlorate Cu(Ⅱ) hexahydrate hexamethanol is higher than others, IC 50 =4.34 .