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血管内皮细胞超极化因子 被引量：2

Endothelium-derived hyperpolarizing factor
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摘要 内皮细胞释放多种重要的生物活性物质 ,调节血管张力、血液纤溶与凝血机制、脂蛋白代谢、免疫反应等重要生命过程。内皮细胞释放的超极化因子 (EDHF)是一类既不同于一氧化氮 (NO) ,也不同于前列环素 (PGI2 )的活性成分 ,可能是花生四烯酸的非前列腺素类代谢物或细胞色素P45 0 ,也可能是K+ 或H2 O2 。EDHF可激活钙依赖性钾通道 ,诱导平滑肌膜电位超极化 ,诱发内皮依赖性舒血管反应。在病理状态下 ,尤其是NO通路障碍时 ,EDHF通路发挥重要作用。 There is another factor involving in endothelium dependent relaxation besides NO, which is independent of cGMP, EDHF. Its hyperpolarization mechanism may be related to the open of calcium dependent K + channels(K + Ca). NO, PGI 2,H 2O 2 and cytochrome P450 derived metabolite of arachidonic acid are all the candidates of EDHF. In the normal blood vessels, the influence of EDHF on endothelium dependent relaxation is little. But in some diseases, when the production and effect of NO is disturbed ,the mechanism of EDHF may play a specially important role.
作者 陈冬梅 汪海
机构地区 军事医学科学院毒物药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2001年第3期249-252,共4页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展规划项目 !(国家 973计划 :G19980 5 112 )
关键词 血管内皮细胞 超极化因子 一氧化氮 钾通道 膜电位 内皮源性舒张因子 endothelium dependent hyerpolarization nitric oxide potassium channels membrane potential endothelium derived relaxing factor
分类号 R322.12 [医药卫生—人体解剖和组织胚胎学]
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参考文献20

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同被引文献26

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中国药理学通报
2001年 第3期

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