摘要
目的:探讨细胞核DNA倍体类型与胃癌预后的关系。方法:应用流式细胞仪(FCM)测定石蜡包埋的胃癌组织细胞核中DNA倍体类型,同时进行生存期随访及观察癌灶周围组织中小静脉、毛细淋巴管癌浸润情况。结果:50例胃癌,二倍体16例(32.0％),异倍体34例(68.0％)。二倍体和异倍体的5年生存率(5-YRS)分别为50.0％、17.6％,癌灶周围小静脉浸润率二倍体和异倍体分别为37.5％和70.6％,淋巴管浸润率二倍体和异倍体分别为43.8％、85.3％。结论:具异倍体的胃癌较二倍体的易发生浸润和转移、预后差,测定DNA倍体模式在评估胃癌预后上有重要作用。
To study the relationship between nuclear DNA ploidy and prognosis of gastric cancer. Methods: Cell nuclear DNA content was analyzed by flow cytometer (FCM) in 50 advanced gastric cancer using paraffin-embedded tissue specimens. The relationship between DNA ploidy pattern and the survival rate was studied. Furthermore, we examined the small veins and lymphatic vessel invasion adjacent to the primary tumor. Results: The diploidy was 16 cases (32.0% ), and aneuploidy was 34 cases (68.0%). The 5-year survival rates of diploidy and aneuploidy patients were 50.0% and 17.6% respectively. Among the diploidy and aneuploidy patients, the venous invasive rates were 37.5% and 70.6% respectively, and the lymphatic vessel invasive rates were 43.8% and 85.3% respectively. Conclusion: The poor prognosis in patients with aneuploidy tumor is obtained than that in diploidy tumor patients. The measurement of DNA ploidy pattern is important in evaluating prognosis of gastric cancer.
出处
《天津医药》
CAS
北大核心
2001年第7期397-398,I001,共3页
Tianjin Medical Journal
