摘要
目的探讨血管紧张素 受体拮抗剂洛沙坦治疗糖尿病肾病 (DN)的疗效及安全性。方法 37例 DN并发肾功能不全者随机分为二组 ,分别接受洛沙坦、依那普利治疗 ,于治疗前、治疗后 2、4、8、12周测定血压、血肌酐、尿素氮、尿酸 ,及 2 4小时尿蛋白、尿白蛋白定量等各项指标变化。结果两组均有明显的降压效果 (P<0 .0 1)及降低尿蛋白的排泄作用 (P<0 .0 1) ;洛沙坦组尿蛋白平均下降40 .3% ,依那普利组尿蛋白下降 37.5 % ;两组血尿素氮、血肌酐有所下降 ,但没有显著性差异 (P>0 .0 5 )。洛沙坦有明显的降血尿酸作用 (P<0 .0 1) ,疗效优于依那普利组。结论洛沙坦对 DN有良好的肾脏保护作用 ,副作用少 。
Objective To investigate the protective effects of angiotensin Ⅱ receptor antagonist losartan on diabetic nephropathy (DN).Methods 37 DN cases complicated by renal insufficiency were divided into two groups which were treated with losartan and enalapril,respectively.Blood pressure,plasma creatinine,blood urea nitrogen (BUN),uricemia,urinary protein and albumin were measured before and at 2,4,8,12 weeks after treatment.Results Losartan and enalapril lowered blood pressure remarkably (P<0.01) and reduced urinary protein (P<0.01),with an average decrease of 40.3% and 37.5% respectively.There was a little decrease but no significant differences in BUN and plasma creatinine between the two groups (P>0.05).Losartan decreased uricemia remarkably (P<0.01).Conclusion Losartan has a renal protective effect with few side effects.
出处
《中国综合临床》
北大核心
2001年第6期432-433,共2页
Clinical Medicine of China
