单倍剂量增强MR主动脉造影

Single-dose contrast-enhanced magnetic resonance aortography

目的 探讨单倍剂量增强磁共振主动脉造影 (CEMRA)的可行性及其临床应用价值。方法 2 8例健康成人行循环时间 (TT)和主动脉强化峰值持续时间 (DPE)测试 ,比较 2ml/s、3ml/s 2种注射速度时TT、主动脉峰值信号 (SPE)、DPE和DPE与注射时间 (TI)的差值 (ΔT) ;正常志愿者分 2组 ,每组 10例 ,分别以 2ml/s、3ml/s的注射速度作三维稳态快速激发序列 (3DFISP)的单倍剂量CEMRA ,比较不同注射速度CEMRA原始图的信噪比及CEMRA影像 ;15例主动脉病变患者行 3ml/s注射速度的单倍剂量CEMRA。结果 2ml/s与 3ml/s注射速度下分别测得TT为 (9 6± 1 7)s和 (7 6± 1 5 )s,SPE为 92 0± 10 5和 113 0± 7 6 ,DPE为 (11 5± 1 5 )s和 (8 5± 0 5 )s及ΔT为 (4 8± 0 9)s和(4 0± 0 2 )s ,CEMRA信噪比为 6 0± 2和 80± 2 ,两组间均有显著性差异 (P <0 0 1)。15例主动脉病变的单倍剂量CEMRA图像清晰 ,主动脉病变的大小、范围及主动脉各大分支动脉显示清楚。结论 单倍剂量CEMRA在理论上和技术上可满足临床诊断需要。

Objective To probe the feasibility of single dose contrast enhanced magnetic resonance aortography(CEMRA) and evaluate its value in clinical application. Methods Transit time(TT) test and duration of peak enhancement of aorta(DPE) test in 28 healthy adults were performed. With 2 different injection rate of Gd DTPA at 2 ml/s and 3 ml/s, the TT,peak signal intensity of aorta(SPE),DPE and the interval between DPE and the time of injection(ΔT) were measured and compared. Two groups of healthy volunteers(each 10) underwent three diamentional fast imaging in static procession sequence (3D FISP) CEMRA with standard dosage of Gd DTPA with the injection rate at 2 ml/s and 3 ml/s respectively. The signal/noise ratio(SNR) of the source images and the image quality of CEMRA of both groups were compared. Fifteen patients with aortic disease did the same study as the voluteers with the injection rate only at 3 ml/s. Results With the injection rate of 2 ml/s and 3 ml/s,the TT,SPE,DPE,ΔT and the SNR of CEMRA in two groups were significantly different( P <0 01) with the value of(9 6±1 7)s/(7 6±1 5)s,92±10 5/113±7 6,(11 5±1 5)s/(8 5±0 5)s,(4 8±0 9) s/(4 0±0 2)s and 60±2/80±2, respectively. High quality CEMRA images were obtained in all 15 patients,in which the size and extent of the aortic anomalies as well as the main branches of aorta were nicely displayed. Conclusion CEMRA with single dose of Gd DTPA is theoretically and technically feasible and can fully meet the clinical diagnostic demand