鼻咽癌患者鼻咽分泌物中肿瘤坏死因子α含量的临床观察

Clinical observation of TNF-α content in nasopharyngeal secretion of patients with nasopharyngeal carcinoma

目的 :探讨鼻咽癌患者鼻咽分泌物中肿瘤坏死因子 α(TNF- α)含量变化的临床意义。方法 :用特制装置收集 2 0例健康者和 5 2例鼻咽癌患者的鼻咽分泌物 ,应用放射免疫技术进行 TNF- α含量测定。结果 :对照组鼻咽分泌物中 TNF- α含量为 (12 .95± 4.6 2 ) pmol/ L,肿瘤组为 (33.6 8± 15 .13) pm ol/ L,肿瘤坏死组为 (6 4.0 0±11.5 7) pm ol/ L。肿瘤组含量明显高于对照组 ,其差异有极显著性意义 (P <0 .0 1) ;肿瘤坏死组含量进一步升高 ,与肿瘤组比较 ,其差异亦有极显著性意义 (P<0 .0 1)。结论 :鼻咽癌患者鼻咽分泌物中 TNF- α含量高于正常人 ,测定鼻咽分泌物中 TNF- α含量有助于鼻咽癌的诊断。

Objective:To detect the changes of tumor necrosis factor α(TNF α) in nasopharyngeal secretion of patients with nasopharyngeal carcinoma(NPC).Method: The content of TNF α in nasopharyngeal secretion was determined by radioimmunoassay (RIA) in 20 controls,52 patients with NPC.Result:The average concentrations of TNF α were ( 12.95 ± 4.62 )pmol/L in control group,( 33.68 ± 15.13 ) pmol/L in NPC group and ( 64.00 ± 11.57 )pmol/L in NPC with necrosis group. The content of TNF α in nasopharyngeal secretion in control group was lower significantly than that of patients with NPC (P< 0.01 ).Conclusion:The level of TNF α in nasopharyngeal secretion of NPC patients was higher than that of normal subjects. To detect the content of TNF α in nasopharyngeal secretion is a useful test for the study and diagnosis of NPC.