摘要
目的 探讨电针镇痛后效应的中枢机制。 方法 以急性佐剂性关节炎 (AA)大鼠作为炎症痛模型 ,以“昆仑”穴为电针穴位 ,以放免、荧光测定为检测方法 ,观察了炎症局部痛阈、脑干 5 -羟色胺 (5 -HT)含量、下丘脑β-内啡肽 (β- EP)含量。 结果 电针能提高 AA大鼠痛阈并能维持 6 0 m in以上 ;提高下丘脑β- EP含量并维持 30 m in以上 ;提高脑干 5 - HT含量并维持此效应 30 min以上。 结论 提示电针镇痛后效应有其客观的中枢机制。
Objective To study the central mechanism of the after effect of acupuncture analgesia. Methods The acute adjuvant arthritis rat was selected as inflammatory pain model, and the kunlun acupoint of rat was given electroacupuncture stimulation, then the pain threshold of the inflammatory region was measured, the contents of 5-hydroxytrytamine in brain stem and β-endorphin in hypothalamus was detected with the methods of radio immunoassay (RIA) and fluorimetric determination. Results EA could raise the pain threshold of AA rat, which lasted for over 60 min; raise the content of β-EP in hypothalamus, which lasted for over 30 min; raise the content of 5-HT in the brain stem, which lasted for over 30 min. Conclusion The above results suggested that EA analgesic effect had central mechanism.
出处
《上海针灸杂志》
2001年第3期37-39,共3页
Shanghai Journal of Acupuncture and Moxibustion
