早期生活-阿尔茨海默病发病的危险因素

Childhood-life: risk factors for the development of .Alzheimer's disease.

目的 研究早期生活因素与阿尔茨海默病（AD）的关系。方法 在社区基础上行病例对照研究（病例组和对照组各11例）。研究这些病例25岁以前的居住地、教育、出生时母亲年龄、父亲年龄、同胞个数及家中排行。结果 兄弟姐妹人数每增加一个,发病的危险性增加2％（OR=1.02）;同胞数7个以上者患AD的危险性是7个以下的4.19倍（OR=4.19）;出生时母亲年龄在35岁以上的患病危险性高（OR=1.25）;出生排行中,排行每增加一个,患病危险性增加26％（OR=1.26）。早期生活在农村的低文化者患病危险性（OR=2.14,95％CI=1.05-4.87）高于其他环境的患者。结论 早期生活因素和环境因素与阿尔茨海默病发生的危险性有关,低文化本身可能是这些因素的一个伴随标记。

Objective To investigate the relationship between childhood-life factors and the development of Alzheimer's dis-ease(AD) . Methods In a community-based case-control study, we examined the variables including residence area, education, mother's age at the time of patient's birth, father's age at the time of patient's brith, the numbers of siblings and birth order before the age of 25 years. Results For each additional sibling in the family the risk of AD increased 2 % ( OR = 1.02). The risk of AD when sibship size was more than seven was four times that of sibship size being less than seven(OR = 4.19) . For each additional birth order the risk increased 26%(OR= 1.26) . The risk of having low education and rural residence was higher than others (OR = 2.14, 95%CI = 1.05 - 4.87) . Conclusions The childhood-life and early environment was associate with the risk of developing AD. It is possible that low education is an accompanying marker for these risk factors.