人工虫草提取物抗心律失常作用的研究

Antagonistic Effects of Extracts from Cultural Mycelium of Cordyceps sinensis on Arrhythmia

目的 :利用乌头碱、氯化钡所致大鼠心律失常模型比较人工虫草提取物对实验性心律失常的保护作用。方法 :采用乌头碱 ,氯化钡分别制备心律失常实验模型 ,观察虫草提取物的保护作用。结果 :人工虫草菌丝体石油醚提取物抗心律失常作用较强 ,可明显对抗乌头碱所致大鼠的心律失常 ,延长心律失常的诱发时间 ,降低心律失常持续时间及严重程度 ;对氯化钡所致心律失常也有一定的对抗作用 ,可降低心律失常严重程度。结论

AIM The purpose is to study the anti arrhythmic effects of extracts from cultured \%Cordyceps sinensis\%. METHODS Aconitine and barium chloride were used to induce experimental arrhythmia models in rats. RESULTS The results showed that PE was more potent than other ingredients. Pretreatment with PE by oral administration significantly antagonized arrhythmia induced by aconitine. PE significantly prolonged the onset of arrhythmia, decreased the duration and diminished the degree of severity. And in barium chloride induced arrhythmia model, PE had some anti arrhythmia effect,which could diminish the degree of severity effectively to some extent. CONCLUSION PE is an active component to antagonize arrhythmia induced by aconitine and barium chloride.