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最佳反义药物的选择 被引量:2

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摘要 在反义实验中成功的关键是选择合适的靶位点。但是 ,由于RNA折叠形成二级结构 ,会使大多数互补的核酸不能接近并形成分子间的碱基配对 ,因此这种选择非常困难。通常采用的方法 ,如“序列步移”或计算机辅助设计 ,并未获得显著的成功。为此 ,本文总结了几个经验选择方法 ,特别是基于转录物的RNaseH图谱和寡核苷酸芯片扫描的方法。
出处 《国外医学(药学分册)》 2001年第3期136-140,共5页 Foreign Medical Sciences(Section of Pharmarcy)
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