摘要
受体介导的基因给药系统是非病毒性载体发展的重点。通过对靶向载体进行结构改造 ,可以避免DNA/载体复合物与血浆蛋白的相互作用 ,促进DNA从内吞体的释放和向细胞核的转运 ,改善体内过程 ,提高靶向性。
出处
《国外医学（药学分册）》
2001年第3期157-160,共4页
Foreign Medical Sciences(Section of Pharmarcy)
参考文献23
-
1[1]Li S, Huang L. Nonviral gene therapy: promises and challenges[J]. Gene Ther, 2000, 7(1):31-34.
-
2[2]Wagner E. Application of membrane-active peptides for nonviral gene delivery[J]. Adv Drug Deliv Rev, 1999,38(3) :279- 289.
-
3[3]Wu GY, Wu CH. Receptor-mediated delivery of foreign genes to hepatocytes[J]. Adv Drug Deliv Rev, 1998, 29(3):243-248.
-
4[4]Zanta MA, Boussif O, Adib A, et al. In vitro gene delivery to hepatocytes with galactosylated polyenthylenimine[J].Bioconjug Chem, 1997, 8() :839 - 844.
-
5[5]Wagner E, Cotten M, Foisner R, et al. Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells [J]. Proc Natl Acad Sci USA, 1991, 88(10) :4255 - 4259.
-
6[6]Jenkins RG, Herrick SE, Meng QH, et al. An integrintargeted non-viral vector for pulmonary gene therapy [J].Gene Ther, 2000, 7(5):393-400.
-
7[7]Erbacher P, Remy JS, Behr JP, et al. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathways[J]. Gene Ther, 1999, 6(1): 138 - 145.
-
8[8]Kircheis R, Kichler A, Wallner G, et al. Coupling of cell binding ligands to polyethylenimine for targeted delivery[J].Gene Ther, 1997, 4(5) :409 - 418.
-
9[9]Plank C, Machtler K, Szoka FC Jr, et al. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery[J]. Human Gene Ther,1996, 7(12):1437- 1446.
-
10[10]Ross PC, Hui SW. Lipoplex size is a major determinant of in vitro lipofection effficiency[J]. Gene Ther, 1999,6(4) :651 - 659.
同被引文献8
-
1MRYASHITA T,REED J C.Bcl-2 gene transfer increase relative resistance of S49.1 and WEH 17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids multiple chemotherapeutic drugs[J].Cancer Res,1992,52(19): 5407-5411.
-
2UCKEN F M,YANG Z,SATHER H,et al.Cellular expression of antiapoptosis bcl-2 oncoprotein in newly diagnosed chinaren's cancer group study[J].Blood,1997,89(10): 3769-3777.
-
3LEI X Y,ZHANG H,HE D M.Apoptosis induced by Bcl-2 antisense peptide nucleic acid in HL60[J].Chinese-German Journal of Clinical Oncology,2002,2(1): 36-38.
-
4ZHANG Y,LEI X Y.Effect of bcl-2 antisense on drug-sensitivity of leukemic cells[J].Hematology Journal,2003,4(3): 187-197.
-
5ZHANG Y,SHEN W L.Antisense of bcl-2 increases the susceptibility of leukemic cells to arsenic trioxide-induced apoptosis[J].Cell Biology International,2003,27(12): 953-958.
-
6OSORIO L,JONDAL M,AGUILAR-SANTELISES M,et al.Regulation of B-CLL apoptosis through membrane receptors and Bcl-2 family proteins[J].Leukemia and Lymphoma,1998,30(3/4): 247-256.
-
7RADER C,SINHA S C,POPKOV M,et al.Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst[J].Proc Natl Acad Sci USA,2003,10(9): 5396-5400.
-
8邱莲女.Bcl-2与肿瘤关系的研究进展[J].国外医学（临床生物化学与检验学分册）,2000,21(4):196-199. 被引量：11
-
1许道松.外源基因的靶向细胞表达[J].国外医学（分子生物学分册）,1998,20(3):104-107.
-
2李煜,综述,钱关祥,审校.基因治疗中的病毒性载体研究进展[J].上海第二医科大学学报,2000,20(3):280-282.
-
3吴红珍,张林波.全细胞差减筛选法在噬菌体展示文库筛选中的应用[J].中国生物制品学杂志,2012,25(2):243-245. 被引量：3
-
4金浩承,邵长周,何礼贤.树突状细胞的抗原递呈及临床应用前景[J].国际呼吸杂志,2005,25(S1):6-10. 被引量：3
-
5洪锦心.抗体分子结构改造与基因工程抗体[J].生物科学信息,1991,3(4):1-6.
-
6徐昊,王明荣,颜光涛.脂质体转染技术进展及其应用[J].国外医学（预防．诊断．治疗用生物制品分册）,2000,23(6):263-265. 被引量：6
-
7许晓楠,张红梅,安利佳.基因治疗中载体的研究进展[J].医学新知,2001,11(4):199-201. 被引量：1
-
8李振宇,徐开林,潘秀英,鹿群先,何徐彭,孙海英,主鸿鹄.HIV-1慢病毒载体的构建及结构改造[J].中华血液学杂志,2004,25(9):571-572. 被引量：21
-
9蔡立英.给药:大脑的食物[J].世界科学,2014(8):40-41.
-
10周炼红,胡燕华.眼基因治疗中载体的选择[J].国外医学（眼科学分册）,2004,28(6):370-373.
