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疫苗输送系统的研究进展 被引量：3

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摘要 本文综述了近年来缓释给药、控释给药、靶向给药等制剂新技术在疫苗输送系统中的应用 ,同时综述了经胃肠道和粘膜等途径输送疫苗的研究进展 ,其中疫苗缓释输送系统是研究最活跃的领域之一。这些输送系统的研究对于免疫途径的多样化以及疫苗新剂型的多样化、减少接种次数等方面具有重要意义。
作者 晏四平 全东琴
机构地区 北京三元基因工程有限公司 军事医学科学院毒物药物研究所
出处 《国外医学（药学分册）》 2001年第3期174-178,共5页 Foreign Medical Sciences(Section of Pharmarcy)
关键词 疫苗输送系统 缓释系统 脉冲释放
分类号 R186 [医药卫生—流行病学]
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参考文献23

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同被引文献38

  • 1郭涛,郑春丽,宋洪涛,隋因,党大胜,孙学惠.双氯芬酸钠脉冲控释微丸的研究[J].药学学报,2003,38(9):707-710. 被引量：15
  • 2冯利,周兴军,王世聪,姜杨,齐宪荣.单剂HBsAg-PLGA控释疫苗微球小鼠体内免疫学研究[J].药学学报,2006,41(2):132-137. 被引量：5
  • 3Wang ZY,Zhao YM,Fang W,et al. Syntheses of poly Serial Biodegradable Polymer Materials via Direct Melt Polycondesation and Their Characterization[J]. J Appl Poly Sci,2006,99(2) : 244- 252.
  • 4Weert M, Hennink WE, Jiskoot W. Protein instability in poly (lactide-co-glycolide) microparticles [J]. Pharm Res, 2000, 17 (10):1159-1167.
  • 5Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) [J]. Nat Biotechnol, 2000,18( 1 ) : 52-57.
  • 6Takenaga M, Yamaguchi Y, Kitagawa A, et al. A novel sustainedrelease formulation of insulin with dramatic reduction in initial rapid release[J]. J Control Release,2002,79(1-3):81-91.
  • 7Walter E,Dreher D, Kok M, et al. Hydrophilie poly-(dl-lactideco-glyc-olide) rnicrospheres for the delivery of DNA to human insulin macrophages and dendritic cell [J]. J Controlled Release,2001,76(1-2):149-168.
  • 8Stubbe B G, De Smedt S C, Demeester J. "Programmed polymerie devices" for pulsed drug delivery[J]. Pharm Res, 2004, 21 : 1732-1740.
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  • 10Cleland J L, Lim A, Barron L, Duenas E T, Powell M F. Development of a single-shot subunit vaccine for HIV-1 :Part 4. Optimizing microencapsulation and pulsatile release of MN rgp120 from biode gradable microspheres[J].J Contr Rel, 1997,47:135-150.

引证文献3

二级引证文献5

国外医学（药学分册）
2001年 第3期

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