老年男性冠心病血中CNP,ET,NO测定及意义

Detection and Significance of CNP, ET, NO of Blood in Old Male Patients with CHD

目的 检测老年男性冠心病患者血浆CNP ,ET和血清NO的含量 ,探讨其临床意义。方法 冠心病组男性 33例、正常对照组男性 30例 ,采用RIA测定血浆CNP和ET ,镉还原法测定血清NO。结果 冠心病组血浆CNP ,ET含量均明显高于正常对照组 (分别为P <0 .0 1,P <0 .0 5 ) ,血清NO含量明显低于正常对照组 (P <0 .0 1)。结论 血中CNP ,ET和NO参与了冠心病的发生发展过程 ,检测其含量变化对于患者病情观察、预后判断具有重要意义。

Objective The content of CNP、ET and NO in blood of old male patients with coronary heart disease (CHD) were detected. Method There were 33 men with CHD and 30 controls. CNP and ET in plasma were detected by RIA. NO in serum was detected by cadmium reduction method. Result The content of CNP and ET in plasma of CHD group was higher than controls significantly (P<0.01 and P<0.05). The content of NO was lower than controls significantly (P<0.01). Conclusion The detection of CNP、ET and NO has important significance for observation of patients condition and judgement of prognosis in patients with CHD.