精神分裂症患者IgG,IgA,IgM及C_3,C_4含量分析

Analysis of Immunoglobuin and Complement of Schizophrenic

目的 探讨体液免疫异常在精神分裂症发病过程中的作用。方法 利用速率散射比浊法测定 2 5例首发精神分裂症患者、30例经抗精神病药物治疗患者血清中IgG ,IgA ,IgM及补体C3,C4 含量 ,并与正常人作对照分析。结果 未治疗组血清中IgG ,IgA含量显著高于正常人及治疗组 (P <0 .0 1) ,而IgM则无显著性差异 (P >0 .0 5 ) ,治疗组及未治疗组血清C3 含量显著低于正常对照组 (P <0 .0 1)。结论 精神分裂症存在一定程度的体液免疫异常 ,在其发病机理上起到一定的直接或间接作用。

Objective To study the value of humoral immunity change in schizophrenia. Method The concentration of IgG, IgA, IgM and C 3, C 4 of 25 patients with shizophrenia before treatment as well as 30 patients with shizophrenia after treatment were determined by rate scatter turbid assays. Result The concentration of IgG, IgA of no treament group were obviously higher than that of treament group and normal people (P<0.01). IgM was not clear (P>0.05), but the level of C 3 in both two groups were lower obviously than normal people (P<0.01). Conclusion The schizophrenia has abnormal humoral immunity change and it has direct or indirect function in pathogenesis.