56例口腔鳞癌患者HPV感染和p53蛋白表达的临床病理学意义

The Alterative Expression of p53 and Infections of HPV in Uygur Patients with Oral Squamous Cell Carcinoma in Xinjiang

应用免疫组化ＬＳＡＢ法检测５６例口腔鳞癌患者ｐ５３蛋白的表达及变化，用ＰＣＲ技术检测ＨＰＶ感染率，探讨人乳头状瘤病毒（ＨＰＶ）感染及抑癌基因ｐ５３在维吾尔族口腔鳞癌患者中的异常表达与肿瘤病理生物学特征间关系及临床病理学意义，为维吾尔族口腔鳞癌有效防治提供实验科学依据。本研究得出：（１）免疫组化法检测抑癌基因ｐ５３在细胞内的表达可对良恶性病变从分子水平进行评估，并可作为早期诊断及临床治疗口腔鳞癌的分子生物学指标；（２）ＨＰＶ１６、１８型感染与口腔鳞癌的发生密切相关，可能是口腔鳞癌发生中的重要环节。

Expression of p53 in tumor tissues of 56 Uygur patients was detected by immunohistochemistry (LSAB) and HPV infection in oral squamous cell, carcinoma tissues were detected by PCR. The alterative expression of p53 and infections of HPV in tumor tissues of oral squamous cell carcinoma in Uygur patients relating with the biopathology and clinical significance was studied,that can provide scientific basis for effective prevention and cure this tumor. Conclusion could be reached as follows: (1) Immunohistochemically examining the alterative expression of tumour-suppressor gene p53, may offer useful molecular index for the early diagnosis, clinical therapy of OSCC. (2)The results suggest that HPV 16,18 infection play an important role in carcinogenesis of OSCC.