硝苯吡啶治疗脑血栓时血小板聚集功能变化

When nicodipine cures brain thrombus platelet of gathering function changes

本文报道40例脑血栓患者,经口服硝吡苯啶药物治疗,有效率为87.5％,显效率为72.5％,其作用机制与硝苯吡啶能部分抑制缺血后细胞外钙离子进入细胞内,减少缺血性脑损伤有关。在用药前后采用两种诱导剂做了血小板聚集功能动态观察,治疗前血小板聚集性明显高于正常人(P<0.01)。提示:脑血栓患者血小板聚集性增高是形成血栓的关键。治疗后血小板聚集功能明显低于治疗前(P<0.01),说明硝苯吡啶具有降低血小板聚集功能,可能是钙离子拮抗剂抑制钙离子促发血小板聚集作用所致。

This article report forty brain thrombus patient who is cured with nicodi- pine by per oral that the efficacious is 87.5 percent, obvious efficiency is 72.5 percent. Its function is connected with that the nicodipine keep in part brain oit of blood later outer Ca^(++) of cellula come in the cellula to reduce brain out of blood destroied. To use the nicodipine it needs two inducing agents to do a observation about the platelet of gathering function. Prior-treatment the brain thrombus patient's the platelet of assembling profit is obvious higher than the normal person(p<0.01). Explanation: the brain thrombus patient whose the platelet of assembling profit increase is led to thrombus key. After treatment the platelet of gathering function is obvious lower than prior trea tment (p<0.01), express the nicodipine has a function reduce the platelet of gathering function that Ca^(++) of antagonist keeps Ca^(++) to cause the platelet of gathering function probability.