德州市育龄妇女破伤风抗体水平监测分析

Dynamic surveillance of anti-tetanus antibody among child-bearing age women in Dezhou, 1988-1999

为了解德州市育龄妇女破伤风免疫状况及长期变动趋势 ,于 1988- 1999年间对 18- 35岁育龄妇女破伤风抗体水平进行了动态监测 ,共监测 6次 ,735人。监测结果基本反映了我市人群破伤风类毒素免疫工作开展情况。 1988- 1991年间育龄妇女破伤风抗体水平和阳性率均较低 ,其均值分别为 0 0 30 2IU/ml和 44 2 5 % ;1993年抗体水平和阳性率明显提高 ,之后较为稳定 ,1993- 1999年间抗体水平和阳性率均值分别为 0 0 5 91IU/ml和 73 13%。城市地区育龄妇女破伤风抗体水平和阳性率明显高于农村地区 ,不同年龄间妇女抗体水平和抗体阳性率差异无显著意义 ,育龄妇女和同龄男性的破伤风免疫状况也无明显差异。为消除新生儿破伤风的发病因素 ,建议进一步做好对育龄妇女的破伤风类毒素免疫工作。

In order to detect the immune state and dynamics of serum anti-tetanus antibody among child-bearing age women in Dezhou city, serum antibody was measured in 735 women in age of 18-35 for six times from 1988 to 1999. The average concentration and serum positive rate of anti-tetanus antibody were 0.0302IU/ml, and 44.25%, respectively, in 1988-1991. In 1993, both antibody concentration and serum positive rate were increased significantly as compared with the last several years. Since 1993, the antibody concentration and the serum positive rate approached to a steady period. The average concentration and serum positive rate were 0.0591IU/ml, and 73.13%, respectively, during 1993-1999. Both antibody concentration and serum positive rate were higher in urban women than those in rural women. No significant difference was found between each age groups. When compared with men in the same age group, no sinificant difference was found as well. In order to eradicate neonatal tetanus, improving tetanus immunization in child-bearing age women was suggested.