急性心肌梗塞重组链激酶早期溶栓血液流变学研究

The study to the indexes of hemorheology in acute myocardial infarction with recombinant strepatokinase intravenous thrombolysis

目的观察急性心肌梗塞重组链激酶早期静脉溶栓前后血液流变学变化 ,探讨其变化规律 ,为临床诊断、治疗提供依据。方法对36例急性心肌梗塞患者早期重组链激酶溶栓 ,分别于溶栓开始前、溶栓治疗后3小时采血样进行血液流变学检查。结果急性心肌梗塞患者的各项血流变学指标均明显异常。重组链激酶早期静脉溶栓后各项血液流变指标均明显改善。尤以纤维蛋白原、血小板聚集率、凝血酶原时间、红细胞刚性指数为著。结论重组链激酶在急性心肌梗塞早期静脉溶栓治疗方面 ,能明显改善血液流变学各项异常指标 ,对缩小梗塞面积 ,恢复心肌灌注 ,减少并发症 ,防止梗塞后心绞痛及再梗塞的发生、改善预后具有十分重要的作用。

Objective To observe the effect of indexes of hemorheology in acute myocardial infarction (AMI) before intravenous thrombolysis with recombinant strepatokinase (r_SK) and after thrombolytic therapy respectively. Methods To examine the blood sample, before intravenous thrombolysis with recombinant strepatokinase and after three hours of therapy in 36 patients with AMI. Results The whole indexes of hemorheology in the patients with AMI were abnormal, which were evidently improved after intravenous thrombolysis with r_SK, such as fibrinogen (Fg) prothrmbin time (PT) and platelet aggregation test(PAGT). Conclusions The using of r_SK in AMI early can improve the indexes of hemorheology evidently, and it can play an important role in the shrinking the area of infarction, recovering reperfusion rate and redaving mortality rate.