血管紧张素Ⅱ受体拮抗剂在治疗小儿心力衰竭中的临床研究

Experimental Study of the Angiotensin Ⅱ Recepter Anlagonist in the Therapy of Child's Congetive Heart Failare

目的 :探讨血管紧张素Ⅱ受体拮抗剂在小儿心力衰竭中的实际治疗效果 ,为临床治疗小儿心力衰竭探索新的治疗手段。方法 :对 4 0例不同原因所致的小儿充血性心力衰竭患儿随机分成口服血管紧张素Ⅱ受体拮抗剂组 (治疗组 )和口服安慰剂组 (对照组 )。两组在服药前及服药后 4 8小时均测算左心室收缩期短轴缩短分数 (LUSF)、左室射血分数 (EF) ,及肺动脉收缩压 (PASP)。结果 :治疗组LUSF和EF增加显著高于对照组 ;PASP增加明显大于对照组。结论

Objective To evalute the therapeutic effect of angiotensin Ⅱ receter antagonist in Child's congestive heart failure and to investigate the new therapeutic means in child's congestioe heart failure.Methods:Forty patients with congestiv heart failure led up to different causes were randomly classified into the taking-in angiotensin Ⅱrecepter antagonist group(experimental group)and the taking-in comfortable tablets group (control group).Two group were detected LVSF,EF and PASP before taking-in tablets and after taking-in tablets for 48 hours.Result:LVSF,EF AND PASP of the experimental group were significantly increased as compared with the control group.Conclusion:Angiotensin Ⅱ recepter antagonists may play a main role in the increasing heart function.