脑脊液铜、锌水平与老年期痴呆的关系

Effect of the concentration of Copper and zinc in the CSF on vascular dementia and Alzheimer′s Disease.

目的 探讨脑脊液 (CSF)铜、锌与老年期痴呆的关系。 方法 对 5 8例老年血管性痴呆 (VD)患者和 3 8例老年阿尔茨海默病 (AD)患者及 3 2例健康体检者 (对照组 )的CSF行铜、锌浓度和蛋白检测。 结果 与对照组相比 ,VD组和AD组CSF铜有显著性升高 (P <0 0 1) ,铜 /锌的异常率达 62 1%和 60 5 % ,大于铜 (5 0 % ,42 1% )、蛋白 (41 4% ,8% )和锌 (3 4% ,8% )的异常率。AD组CSF锌有显著性降低 (P <0 0 5 ) ;VD组和AD组相比 ,铜、蛋白和锌都有显著性差异 (P <0 0 5 )。 结论 CSF铜、锌与老年性痴呆关系密切 ,在一定程度上反映了该类疾病与铜、锌参与的免疫和代谢有关。对于该疾病的诊断 ,铜 /锌较其他

Objective To investigate the relationship between vascular dementia(VD)and Alzheimer′s disease(AD)and the concentration of copper and zinc in the CSF. Methods The copper and zinc and total protein in the CSF were tested in 58 cases of vascular dementia and 38 cases of Alzheimer′s disease and 32 cases of the normal group. Results Compared with the normal group,the copper in the CSF of the two groups of patients increased significantly ( P <0 01)with the abnormal rate of copper/zinc being 62 1% and 60 5%,which had advantage over the rate of copper(50%,42 1%)and protein(41 4%,8 0%)and zinc(3 4%,8 0%).The zinc of Alzheimer′s group is lower than that of the normal group.There was significant difference in zinc concentrtion between the groups of VD and AD. Conclusions Copper and zinc levels in CSF are closely related to vascular dementia and Alzheimer′s disease.It indicates that these diseases are closely related to immune and metabolism involved by copper and zinc.The copper/zinc ration is more valuable in diagnosis of the vascular dementia and Alzheimer′s disease.